Publications
Peer-reviewed research advancing our understanding of immune cell biology, tumor microenvironments, and therapeutic interventions.
Incretin Triple Agonist Retatrutide (LY3437943) Alleviates Obesity‑Associated Cancer Progression
Marathe SJ, Grey EW, Bohm MS, Joseph SC, Ramesh AV, Cottam MA, Idrees K, Wellen KE, Hasty AH, Rathmell JC, Makowski L
npj Metabolic Health and Disease
Calorie restriction increases insulin sensitivity to promote beta cell homeostasis and longevity in mice
Dos Santos C, Cambraia A, Shrestha S, Cutler M, Cottam M, Perkins G, Lev‑Ram V, Roy B, Acree C, Kim KY, Deerinck T, Dean D, Cartailler JP, MacDonald PE, Hetzer M, Ellisman M, Arrojo E Drigo
Nature Communications
Transcriptomic Plasticity of the Circadian Clock in Response to Photoperiod: A Study in Male Melatonin-Competent Mice
Cox OH, Giannoni-Guzmán MA, Cartailler JP, Cottam MA, McMahon DG
Journal of Biological Rhythms
Gli2 Overexpression Alters the Differentiation Status of Dedifferentiated Liposarcoma Cells and Results in an Immunosuppressive Myeloid Phenotype in Orthotopic Tumors
Bennett NE, Beadle EP, Parker DV, Coe EJ, Cottam MA, Baum JE, Miller JS, Serrenho JA, Rhoades JA
bioRxiv
Disruption of nucleotide biosynthesis reprograms mitochondrial metabolism to inhibit adipogenesis
Pinette JA, Myers JW, Park WY, Bryant HG, Eddie AM, Wilson GA, Montufar C, Shaikh Z, Vue Z, Nunn ER, Bessho R, Cottam MA, Haase VH, Hinton AO, Spinelli JB, Cartailler JP, Zaganjor
Journal of Lipid Research
Effect of chemotherapy on passenger mutations in metastatic colorectal cancer
Siddiqui MT, Cottam MA, Mirza MB, Keeli LB, Kristen CK, Washington K, Idrees
Under review at Molecular Oncology
Regulatory Macrophages Contribute to Tumor Cell Plasticity in Colorectal Cancer Metastases
Cottam MA, Mirza MB, Arner EN, Siddiqui MT, Marincola Smith P, Piscombe C, Revetta F, Hatem Z, Tasneem N, Cameron A, Beckermann KE, Edwards J, Rathmell JC, Lau KS, Washington MK, Jamieson NB, Raoof M, Idrees K
In revision
Empagliflozin treatment during weight loss does not improve post‑weight regain glucose homeostasis in mice
Bhanot M, Cottam MA, Winn NC, Hasty A
In preparation
Fructose regulates the pentose phosphate pathway and induces an inflammatory and resolution phenotype in Kupffer cells
Lodge M, Scheidemantle G, Adams VR, Cottam MA, Richard D, Breuer D, Thompson P, Shrestha K, Liu X, Kennedy A.
Scientific Reports
Multiomics reveals persistence of obesity-associated immune cell phenotypes in adipose tissue during weight loss and weight regain in mice
ottam MA, Winn NC, Caslin HL, Hasty AH
Nature Communications
Interrupting T Cell Memory Ameliorates Exagger‑ ated Metabolic Response to Weight Cycling
Garcia JN, Cottam MA, Rodriguez AS, Agha AFH, Winn NC, Hasty A
bioRxiv
Comparison of Lean, Obese, and Weight-Loss Models Reveals TREM2 Deficiency Attenuates Breast Cancer Growth Uniquely in Lean Mice and Alters Clonal T-cell Populations
Pierro EW, Cottam MA, An H, Lehmann BD, Pietenpol JA, Wellen KE, Makowski L, Rathmell JC, Fingleton B, Hasty AH
Cancer Research
Weight loss enriches adipose tissue for granzyme K producing clonal CD8+ T cells that induce inflammation in bystander cells during weight regain
Cottam MA, Schleh M, Garcia JN, Winn NC, Hasty AH, Caslin HL
In preparation
PD‑1 is induced on tumor‑associated macrophages in obesity to directly restrain anti‑tumor immunity
Bader JE, Wolf MM, Lupica‑Tondo GL, Madden MZ, Reinfeld BI, Arner EN, Hathaway ES, Steiner KK, Needle GA, Hatem Z, Landis MD, Faneuff EE, Blackman A, Wolf EM, Cottam MA, Ye X, Bates ME, Smart K, Wang W, Pinheiro LV, Christofides A, Smith D, Boussiotis VA, Haake SM, Beckermann KE, Wellen KE, Reinhart‑King CA, Serezani CH, Lee CH, Aubrey C, Chen H, Rathmell WK, Hasty AH, Rathmell JC
Nature
Deletion of Ascl1 in pancreatic ꞵ‑cells improves insulin secretion, promotes parasympathetic innervation, and attenuates dedifferentiation during metabolic stress
Osipovich AB, Zhou FY, Chong JJ, Trinh LT, Cottam MA, Shrestha S, Cartailler JP, Magnuson MA
Molecular Metabolism
Single cell RNA-sequencing suggests a novel lipid associated mast cell population following weight cycling
Caslin HL, Cottam MA, Betjemann AM, Mashayekhi M, Silver HJ, Hasty AH
bioRxiv
Immune profiling of murine cardiac leukocytes identifies triggering receptor expressed on myeloid cells 2 as a novel mediator of hypertensive heart failure
Smart CD, Fehrenbach DJ, Wassenaar JW, Agrawal V, Fortune NL, Dixon DD, Cottam MA, Hasty AH, Hemnes AR, Doran AC, Gupta DK, Madhur MS
Cardiovascular Research
Weight cycling induces innate immune memory in adipose tissue macrophages
Caslin HL, Cottam MA, Pinon JM, Boney LY, Hasty AH
Frontiers in Immunology
Weight cycling impaires pancreatic insulin secretion but does not perturb whole‑body insulin action in mice with diet‑induced obesity
Winn NC, Cottam MA, Bhanot M, Caslin HL, Garcia JN, Arrojo E Drigo R, Hasty AH
Diabetes
ROS‑Degradable Polythioketal Urethane Foam Dressings to Promote Porcine Skin Wound Repair
atil P, Russo KA, McCune JT, Pollins AC, Cottam MA, Dollinger BR, Colazo JM, Yu F, Martin JR, Gupta MK, Cardwell NL, Davison JM, Thompson CM, Brabul A, Hasty AH, Guelcher SA, Duvall CL
Science Translational Medicine
Myeloid‑specific deletion of ferroportin impairs macrophage bioenergetics but is disconnected from systemic insulin action in adult mice
Winn NC, Wolf EM, Cottam MA, Bhanot M, Hasty AH
American Journal of Physiology: Endocrinology Metabolism
Exercise and Adipose Tissue Immunity: Outrunning Inflammation
Winn NC, Cottam MA, Wasserman DH, Hasty AH
Obesity
Kupffer cell release of platelet activating factor drives dose limiting toxicities of nucleic acid nanocarriers
Jackson MA, Patel SS, Yu F, Cottam MA, Glass EB, Hoogenboezem EN, Fletcher RB, Dollinger BR, Patil P, Liu DD, Kelly IB, Bedingfield SK, King AR, Miles RE, Hasty AM, Giorgio TD, Duvall CL
Biomaterials
High CD8 T‑Cell Receptor Clonality and Altered CDR3 Properties Are Associated With Elevated Isolevuglandins in Adipose Tissue During Diet‑Induced Obesity
McDonnell WJ, Koethe JR, Mallal SA, Pilkinton MA, Kirabo A, Ameka MK, Cottam MA, Hasty AH, Kennedy AJ
Diabetes
Links between Immunologic Memory and Metabolic Cycling
Cottam MA, Itani HA, Beasley AA 4th, Hasty A
Journal of Immunology