Matthew A. Cottam, Ph.D. ☕️
Matthew A. Cottam, Ph.D.

Computational Immunologist

Vanderbilt University Medical Center

About Me

Matthew Cottam is an academic research scientist in the Section of Surgical Sciences at Vanderbilt University Medical Center. His interests are at the interface of immunology, intracellular metabolism, and cancer biology in the tumor microenvironment. He is a driving force behind the Kamran Idrees research group, which utilizes data collected from surgically resected specimens to identify ways to improve response to immunotherapy for patients with metastatic cancer.

Download CV
Interests
  • Bioinformatics
  • Next-generation Sequencing
  • Epigenetics
  • Immunology
  • Cancer Biology
  • Immunotherapy
  • Immunometabolism
Education

  • Molecular Physiology and Biophysics

    Vanderbilt University

📚 My Research

I’m a computational immunologist in the Section of Surgical Sciences at Vanderbilt University Medical Center. I leverage next-generation sequencing of human tumor metastases to generate novel immunotherapeutics for use in clinical care.

Please reach out to collaborate.

Featured Publications
Obesity induces PD-1 on macrophages to suppress anti-tumour immunity.
Multiomics reveals persistence of obesity-associated immune cell phenotypes in adipose tissue during weight loss and weight regain in mice
High CD8 T-Cell Receptor Clonality and Altered CDR3 Properties Are Associated With Elevated Isolevuglandins in Adipose Tissue During Diet-Induced Obesity
Links between Immunologic Memory and Metabolic Cycling
Recent Publications
Jackie E. Bader, Melissa M. Wolf, Gian Luica Lupica-Tondo, Matthew Z. Madden, Bradley I. Reinfeld, Emily N. Arner, Emma S. Hathaway, KayLee K. Steiner, Gabriel A. Needle, Zaid Hatem, Madelyn D. Landis, Eden E. Faneuff, Amondrea Blackman, Elysa M. Wolf, Matthew A. Cottam, Xiang Ye, Madison E. Bates, Kyra Smart, Wenjun Wang, Laura v. Pinheiro, Anthos Christofides, DuPreez Smiuth, Vassiliki A. Boussiotis, Scott M. Haake, Kathryn E. Beckermann, Kathryn E. Wellen, Cynthia a Reinhart-King, C. Henrique Serezani, Cheng-Han Lee, Christa Aubrey, Heidi Chen, W. Kimryn Rathmell, Alyssa H. Hasty, Jeffrey C. Rathmell (2024). Obesity induces PD-1 on macrophages to suppress anti-tumour immunity.. Nature.
PDF Cite DOI
Matthew A. Cottam, Heather L. Caslin, Nathan C. Winn, Alyssa H. Hasty (2022). Multiomics reveals persistence of obesity-associated immune cell phenotypes in adipose tissue during weight loss and weight regain in mice. Nat Commun.
PDF Cite DOI
Nathan C. Winn, Matthew A. Cottam, David H. Wasserman, Alyssa H. Hasty (2021). Exercise and Adipose Tissue Immunity: Outrunning Inflammation. Obesity.
PDF Cite DOI
Prarthana Patil, Katherine A. Russo, Joshua T. McCune, Alonda C. Pollins, Matthew A. Cottam, Bryan R. Dollinger, Juan M. Colazo, Fang Yu, John R. Martin, Mukesh K. Gupta, Nancy L. Cardwell, Jeffrey M. Davidson, Callie M. Thompson, Adrian Barbul, Alyssa M. Hasty, Scott A. Guelcher, Craig L. Duvall (2021). ROS-Degradable Polythioketal Urethane Foam Dressings to Promote Porcine Skin Wound Repair.
PDF Cite DOI
Meredith A. Jackson, Shrusti S. Patel, Fang Yu, Matthew A. Cottam, Evan B. Glass, Ella N. Hoogenboezem, R. Brock Fletcher, Bryan R. Dollinger, Prarthana Patil, Danielle D. Liu, Isom B. Kelly, Sean K. Bedingfield, Allyson R. King, Rachel E. Miles, Alyssa M. Hasty, Todd D. Giorgio, Craig L. Duvall (2021). Kupffer cell release of platelet activating factor drives dose limiting toxicities of nucleic acid nanocarriers. Biomaterials.
PDF Cite DOI
See all publications